ORN Fall 2023 - Xylazine - An Introduction to a New Drug-2023-09-06 - Recording - Xylazine

2023-09-06 - Recording - Xylazine - An Introduction to a New Drug

Video Transcription

Video Summary

In this webinar, Dr. Tony Paison discusses the drug Silazine, also known as xylosine. He provides an overview of the drug, including its pharmacology, history, and association with opioid use disorder. Dr. Paison explains that Silazine is an alpha-2 adrenergic agonist and shares similarities with other drugs in this class such as clonidine. He discusses the effects of Silazine, including sedation, hypotension, and bradycardia. Dr. Paison also addresses the association between Silazine and wounds, noting that the cause of these wounds is still unclear. He emphasizes the importance of treating overdose cases involving Silazine with naloxone, despite the drug not specifically targeting Silazine. Dr. Paison also mentions the potential for a withdrawal syndrome associated with Silazine, which may include symptoms such as anxiety and restlessness. He recommends treating Silazine withdrawal with alpha-2 adrenergic agonists, such as clonidine or tizanidine. Overall, Dr. Paison underscores the need for continued research and understanding of Silazine and its impact on opioid use disorder. The webinar was hosted by Julie Kimmick and the funding came from a grant from SAMHSA.

Keywords

webinar

Silazine

pharmacology

opioid use disorder

alpha-2 adrenergic agonist

sedation

wounds

naloxone

withdrawal syndrome

research