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Cannabis (marijuana) use is increasing, with growing commercialization facilitating new trends in cannabis consumption - more daily use and use of higher potency forms of the drug (high % THC or 9-tetrahydrocannabinol, the key psychoactive cannabinoid in cannabis).   Acutely, cannabis produces euphoria, relaxation, reduces stress, but it can also impair cognitive function, coordination and engender anxiety and psychosis. With ongoing use, these adverse effects may be compounded by the development of cannabis use disorder (CUD)   and other neuropsychiatric symptoms or disorders.   The magnitude of adverse consequences and their persistence are associated with dose, use frequency, duration, and age of onset of use. Compared with adult onset, credible evidence has revealed that adolescent-onset and ongoing cannabis use confers a heightened risk of developing addiction, psychosis, cognitive impairment, depression, anxiety, suicidality, with some effects emerging during adulthood. Adolescent vulnerability during this critical phase of adolescent neurodevelopment is foreseeable, as the endogenous endocannabinoid signaling system continues to evolve and contribute to shaping brain architecture. In competing with endocannabinoid agonists at the cannabinoid receptor 1 (CBR1), THC interposes in these exquisitely controlled processes to dysregulate endocannabinoid signaling, triggering incompletely understood neuroadaptive changes. Recent trends of daily use and/or consumption of high potency cannabis products conceivably amplify the overall risks for adolescents, and also in the developing fetal brain. This presentation will describe: 
Recent trends in cannabis use among youth, new and more potent forms of cannabis, and delivery systems, cannabis risks for the developing fetal and adolescent brain and how this information can be used. 

At the conclusion of this seminar, attendees will know and be able to counsel patients on:

• Trends in THC Potency and Delivery Systems
• Trends in THC Potency and Delivery
• Marijuana Risks for Developing Fetal Brain Systems
• Marijuana Risks for Developing Adolescent Brain
• What you can do with this information...

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This webinar has been approved for a maximum 1, AOA Category 1-A CME credits. Physicians should claim only the credit commensurate with the extent of their participation. This activity has been planned and implemented in accordance with the accreditation requirements and policies of the American Osteopathic Association (AOA) and AOAAM. The AOAAM is accredited by the AOA to provide continuing medical education for physicians.

Professor Bertha Madras, PhD (The Honorable)  •    Is a Professor of Psychobiology at Harvard Medical School (at Harvard 37 years), is based at McLean Hospital and is cross-appointed at the Massachusetts General Hospital.  •    Her research has focused on addiction biology, neuropsychiatric disorders, and drug policy.  •    She is  author of more than 200 articles and co-editor of several books.  •    She is a recipient of 19 U.S. and 27 international issued patents with collaborators.  Government Service.  •    Deputy Director for Demand Reduction in the White House Office of National Drug Control Policy (ONDCP), Executive Office of the President, a presidential appointment confirmed by U.S. Senate with unanimous consent.  •    She served as one of six members of the President's Commission on Combating Drug Addiction and the Opioid Crisis, on a World Health Organization panel and a panel on Narcotics at the Vatican Pontifical Academy of Sciences.  •    She is recipient of research and public service awards,  Her experiences in neuroscience research, drug addiction, education, government and public service offer a unique perspective at the intersection of science and public policy.