This lecture examines opioid‑induced androgen deficiency by outlining the mechanisms through which opioid use can affect androgen regulation, reviewing the clinical approach to diagnosing hypogonadism, and summarizing current evidence on testosterone therapy in this setting. Emphasis is placed on understanding biological processes, diagnostic criteria, and reported therapeutic effects.
Dr. Basaria is a Professor of Medicine at Harvard Medical School and Associate Director of the Section of Men's Health, Aging and Metabolism at the Brigham and Women's Hospital. His expertise is in the field of Male Reproduction. His research focuses on understanding the cardiometabolic complications of androgen deprivation therapy in men with prostate cancer and the efficacy of testosterone replacement in men with opioid-induced androgen deficiency.