ORN Fall 2026 - A Randomized Trial of Extended-release Buprenorphine for Opioid Use Disorder Treatment During Pregnancy and for 12-months Postpartum: Results from National Institute on Drug Abuse Clinical Trials Network Study 0080

Description:

This talk will review the key design and primary and secondary outcomes from NIDA Clinical Trials Network Study 0080. This is a landmark study that randomized 140 pregnant adults with moderate-severe opioid use disorder across multiple collaborative care addiction and OB/GYN treatment programs. Participants were randomized to either extended-release buprenorphine (weekly while pregnant, monthly optional post-partum if not breastfeeding) or sublingual buprenorphine. Study treatment was provided through delivery and for 12 months post-partum. Comprehensive effectiveness and safety outcomes for the participating mothers and babies will be shared and discussed.

Learning objectives:

At the conclusion of this seminar, attendees should be able to:

List three clinically significant findings of sublingual buprenorphine and weekly extended-release buprenorphine during pregnancy and the post-partum period.
Explain why rates of non-medical opioid use may have decreased after delivery.
Explain two strengths and two limitations of the study design.

CME

Continuing Medical Education (CME) Credits Available

Participants in this program may earn the following CME credits:

✔ 1 AOA Category 1-A Credit
✔ 1 AMA PRA Category 1 Credit™
✔ 1 AAPA Category 1 CME Credit
✔ 1 Nurses CNE Credit

Earn valuable continuing education credits while enhancing your professional knowledge!

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What is ORN

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Speaker:

Michelle Lofwall MD

Dr. Michelle Lofwall is is a nationally recognized addiction medicine psychiatrist and researcher at the University of Kentucky who specializes in the treatment of opioid use disorder (OUD). Her recent research focuses on improving patient care through the evaluation of novel treatments, such as long-acting buprenorphine, novel workforce training and education, and integrated care models.She has received numerous teaching and mentoring awards, the Nyswander/Dole (Marie) Award from the American Association for the Treatment of Opioid Dependence and is the lead subject matter expert for the forthcoming update of SAMHSA’s Treatment Improvement Protocol on Medication Treatment for Opioid Use Disorder (TIP 63) and member of the National Methadone Access and Quality Commission.

DISCLAIMER

ACCREDITATION:
In support of improving patient care, American Academy of Addiction Psychiatry is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

DISCLOSURE AND CONFLICT OF INTEREST RESOLUTION:
All conflicts of interest of any individual(s) in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners.

Funding:

Funding for this initiative was made possible (in part) by grant no. 1H79TI088037 from SAMHSA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Summary

Availability:

Registration Required

Access expires on Oct 01, 2029

Location:

Online Meeting

Date / Time:

Sep 16, 2026 5:00 PM - 6:00 PM ET

Cost:

FREE

Credit Offered:

1 AAPA Category 1 CME Credit

1 AMA PRA Cat 1 Credit

1 Nurses CNE Credit

1 AOA Category 1A Credit

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