ORN Summer 2024 - Extended-Release Buprenorphine-Recording - ORN Summer 2024- Extended-Release Buprenorphine

Video Transcription

Video Summary

In this detailed webinar, Dr. Anna Marie South, Dr. Alexander Hubbell, and Dr. Simone Base present insightful case studies on the use of extended-release buprenorphine for patients with opioid use disorder (OUD). Dr. South begins with three cases highlighting varied pain management scenarios: a planned surgical intervention, an emergency surgical intervention, and chronic pain due to malignancy. Each case illustrates the individualized and patient-centered approach required, emphasizing the need for proactive pain management strategies and the use of various pharmacological agents to achieve effective analgesia without precipitating a return to opioid use.<br /><br />Dr. Hubbell's discussion then focuses on the use of extended-release buprenorphine in pregnancy. He provides evidence on its efficacy and safety based on recent studies and case reports. He critically examines the risks versus benefits, particularly concerning sublocade containing the excipient N-methyl-2-pyrrolidone (NMP), and shares two case studies of pregnant patients successfully maintained on extended-release buprenorphine. These cases underline the importance of thorough risk-benefit discussions, individualized patient care, and considering alternative formulations like Brixati, which lacks NMP.<br /><br />Finally, Dr. Base presents a compelling case where a patient with unintentional opioid intoxication due to extended-release buprenorphine required surgical removal of the depot. This case highlights the potential risk of administering extended-release buprenorphine to patients without adequate opioid tolerance and outlines the procedural considerations and outcomes of surgical excision.<br /><br />Throughout the webinar, the presenters stress the importance of multidisciplinary collaboration, patient involvement in decision-making, and meticulous clinical documentation to mitigate risks and ensure comprehensive care for patients with OUD.

Keywords

extended-release buprenorphine

opioid use disorder

pain management

pregnancy

sublocade

N-methyl-2-pyrrolidone

Brixati

surgical intervention

multidisciplinary collaboration

clinical documentation