ORN Summer 2024 - Clinical Implications of the Relationship Between Naltrexone Plasma Levels and the Subjective Effects of Heroin in Humans-Recording - Clinical Implications of the Relationship Between Naltrexone Plasma Levels and the Subjective Effects of Heroin in Humans

Recording - Clinical Implications of the Relationship Between Naltrexone Plasma Levels and the Subjective Effects of Heroin in Humans

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Video Transcription

Video Summary

In this webinar, Dr. Felipe Castillo discussed the relationship between naltrexone plasma levels and the subjective effects of heroin in humans. Through a secondary analysis study, it was found that naltrexone plasma levels above 2 nanograms per milliliter blocked the subjective effects of heroin, while levels below this threshold showed greater variability in response. The study highlighted the importance of individualized treatment based on naltrexone plasma levels, with the recommendation of maintaining levels above 2 nanograms per milliliter for optimal therapeutic effect. The discussion also touched on the challenges of naltrexone use in the context of fentanyl, overdose prevention data compared to buprenorphine, and the potential role of pharmacogenomic testing in tailoring treatment strategies. Dr. Castillo emphasized the need for further research in these areas to enhance patient outcomes and reduce risks associated with opioid use disorder treatment.

Keywords

naltrexone

heroin

plasma levels

subjective effects

individualized treatment

fentanyl

overdose prevention

buprenorphine

pharmacogenomic testing